Friday, December 21, 2012

Holiday calendar: Mount Fuji goes fuzzy

DigitalGlobe

A cloud hangs over the summit of Japan's Mount Fuji in this picture from space, captured by DigitalGlobe's WorldView 2 satellite on Sept. 20.

By Alan Boyle

It may look as if a cotton ball is floating over Mount Fuji in this satellite image, but it's actually a cloud?? the kind of cloud that's known to give an otherworldly look to Japan's highest peak.

This picture was snapped by DigitalGlobe's WorldView 2 satellite on Sept. 20, and it's currently the front-runner in the company's contest to select the year's top image. Cast a vote for your favorite on DigitalGlobe's Facebook page, and check back in January to find out which picture wins out.

DigitalGlobe started out with 20 satellite pictures from the past year, and winnowed them down to five finalists. Last week we showed you a different picture from the 20-picture set: a shot of the Tokyo Skytree casting its long shadow on the city. I can understand why the Fuji picture is favored: That cloud definitely adds an air of mystery to the scene. But it's not really all that mysterious: Weather conditions on the mountain lend themselves to strange-shaped lenticular?clouds. (This one?looks totally fake.)

The perspective from above ? 478 miles (770 kilometers) above, to be exact???just adds to the eerieness.

This cottony mountaintop picture is today's offering from the Cosmic Log Space Advent Calendar, which serves up a fresh image of Earth from space every day from now until Christmas. Click on the links below to gather up the goodies you may have missed:


Alan Boyle is NBCNews.com's science editor. Connect with the?Cosmic Log?community by "liking" the log's?Facebook page, following?@b0yle on Twitter?and adding the?Cosmic Log page?to your Google+ presence. To keep up with Cosmic Log as well as NBCNews.com's other science and space news coverage,?sign up for the Tech & Science newsletter, delivered via email. You can also check out?"The Case for Pluto,"?my book about dwarf planets and the search for new worlds.

Source: http://photoblog.nbcnews.com/_news/2012/12/19/16030258-holiday-calendar-mt-fuji-goes-fuzzy?lite

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Gene therapy cocktail shows promise in long-term clinical trial for rare fatal brain disorder

Gene therapy cocktail shows promise in long-term clinical trial for rare fatal brain disorder

Thursday, December 20, 2012

Results of a clinical trial that began in 2001 show that a gene therapy cocktail conveyed into the brain by a molecular special delivery vehicle may help extend the lives of children with Canavan disease, a rare and fatal neurodegenerative disorder.

A report of the trial appears in the Dec. 19, 2012 online edition of the journal Science Translational Medicine.

The form of gene therapy was created and developed at the University of North Carolina School of Medicine. The work was spearheaded by R. Jude Samulski, PhD, a study senior author, professor of pharmacology and director of UNC's Gene Therapy Center. The treatment uses a virus (adeno-associated virus, or AAV) as a "viral vector" meticulously tailored to enter the brain and safely switch good genes for bad.

"This was the first AAV-based gene therapy produced by a U.S. academic institution to be approved for neurological use by the FDA," Samulski said. "It's also the first vector produced by the university's Gene Therapy Center Vector Core facility to go into patients."

Children with Canavan disease have mutations in the ASPA gene that normally codes for an enzyme that helps the brain degrade N-acetyl-aspartate (NAA). The unregulated buildup of NAA is toxic to the brain's gray matter, the protective myelin sheath surrounding nerve cells. As the myelin deteriorates and neurons becoming unable to communicate, the child's head size increases (macrocephaly), there are movement problems such as an inability to crawl, seizures occur, vision becomes impaired, and the children often die within three years of age. Fewer than 1,000 children in the U.S. have the disorder.

Samulski arrived at UNC in 1993 to establish the UNC Gene Therapy Center and has long pioneered methodologies for using viruses to deliver genes effectively and safely to various targets in the body, including the brain, lungs, liver, heart, and muscle. As a graduate student at the University of Florida in the early 1980s, his thesis project was understanding and developing AAV as a vector for delivering therapeutic genes which has help launch this new field of molecular medicine. This work eventually led to development of AAV type 2, which has been used for gene therapy vector trials in cystic fibrosis, hemophilia, Parkinson's diseases, retinal disorders, and in several other settings, including the first gene therapy clinical trial for muscular dystrophy in the U.S developed by Dr. Samulski and his first graduate student, Dr. Xiao Xiao, professor in the UNC Eshelman School of Pharmacy.

In this Canavan disease phase 1/2 safety study, 13 children were treated at the Cell and Gene Therapy Center at the University of Medicine and Dentistry of New Jersey (UMDNJ) in Stratford, N.J. Principal Investigator and first author of the study is Paola Leone, PhD, associate professor of cell biology at UMDNJ. The children were treated in 2001, 2003 and 2005, corresponding to AAV vector production runs. Their ages at the time of treatment ranged from four to 83 months.

Working with Samulski's UNC lab colleagues, Leone's neurosurgical team used MRI imaging to guide them to the proper location and depth in the lateral ventricle of the brain for inserting six very thin catheters via small holes drilled in the skull.

The team then pumped in a solution carrying the vector package containing the replacement ASPA gene. This amounted to about 900 billion genomic particles of replacement gene held by the AAV vector ? roughly the size of a quarter ? that were pumped into each of the six catheter sites. The catheters were then removed.

Following the treatments, the patients went home with their families and were tracked with behavioral tasks and brain imaging studies. The investigators found that the gene therapy was safe and has led to a decrease in NAA in the brain, together with decreased seizure frequency and "clinical stabilization," the greatest observed in youngest patients, those treated before 2 years of age. These include improvements in attention, sleep, and greater degree of movement improvements when lying down and rolling.

"As the trial continued, the FDA let us go to younger and younger patients," Samulski said. "We were successful in being able to treat a 3-months-old infant who was diagnosed in utero ? and that child is alive today and is the youngest person who has ever been treated with gene therapy."

The UNC scientist views the study a definite success from the safety perspective. "The genetic information put into the brains of individuals has not caused adverse effects, toxicity, or cancer. It also has great potential efficacy for treating other degenerative neurological disorders, including Parkinson's and Alzheimer's diseases."

###

University of North Carolina Health Care: http://www.med.unc.edu

Thanks to University of North Carolina Health Care for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126028/Gene_therapy_cocktail_shows_promise_in_long_term_clinical_trial_for_rare_fatal_brain_disorder

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Thursday, December 20, 2012

NewsDaily: Insight: Swiss, facing EU tax pressure, ponder how to ...

Insight: Swiss, facing EU tax pressure, ponder how to attract firms


By Emma Farge
and Caroline Copley
Posted 2012/12/19 at 4:06 am EST

GENEVA, Dec. 19, 2012 (Reuters) ? "Happy Taxation" is a 2011 book by Pascal Broulis, finance minister of the Swiss canton of Vaud and celebrant of the low taxes that distinguish Switzerland. But as times get tougher, discontent about Swiss tax breaks is mounting.

The A-One Business Centre is pictured in Rolle, 30 km (19 miles) east of Geneva, December12, 2012. REUTERS/Denis Balibouse


Cash-strapped foreign governments have already chipped away at the secrecy that allows rich individuals to store tax-free funds in Swiss bank accounts. Now Europe's governments have turned the spotlight on the incentives Switzerland offers companies.

Swiss official company tax rates of around 21 percent compare with 33 percent in France and 29 percent in Germany, according to a 2011 survey by accountants KPMG; often companies in Switzerland actually pay much less. Denknetz, a left-wing Swiss think tank, estimates Switzerland's special tax regimes deprive other countries of up to 36.5 billion francs ($39 billion) in tax revenue each year - almost double the amount Spain's government raised in corporate tax in 2011.

Brussels has demanded that the country, which is home to nearly 24,000 "tax privileged" companies from online retailer eBay to Japanese automaker Nissan, scrap special tax breaks on some company profits.

In particular, the EU is angry that Switzerland's cantons, or states, compete with each other to attract multinationals' business, and charge less tax on foreign-earned income than they do on income earned in Switzerland. Brussels has said the practice, known as "ring-fencing", is the equivalent of providing unauthorized state aid to companies.

Last week the European Commission unveiled a plan to counter inventive tactics increasingly used by big companies to reduce their tax bills, and attacked countries like Switzerland whose policies it says encourage aggressive tax avoidance.

Switzerland is not a member of the European Union but has had a free trade agreement with the EU for the last 40 years. It says it's not doing anything wrong, and it has so far largely ignored the bloc's demands, which were first made in 2005.

In June, EU finance ministers threatened unilateral action if a "satisfactory response" is not communicated by the end of this year. The ultimate sanction would be trade tariffs, which would choke off Swiss industry from Europe, its main trade partner. Member states could take action by coordinating blacklists to be implemented at national level, said Emer Traynor, spokeswoman for the European Commission.

Harmonized EU sanctions would require "a good deal of legal assessment and unanimous agreement in Council", she added.

"It's clear that the EU is not going to back down on this," said Martin Naville, the Swiss CEO of the Swiss-American Chamber of Commerce who co-authored a study on Switzerland's appeal for multinationals. "There has to be a solution and Switzerland will have to give up ring-fencing."

Swiss officials point out that EU countries such as Ireland, which offers a headline corporate tax rate of just 12.5 percent, provide similar tax breaks. Google uses Ireland and the Netherlands to reduce its tax bills.

"We are called a ?tax haven' by some of our European neighbors but Switzerland is far from having the exclusivity on legal devices that allow companies to avoid taxes," Broulis writes in his book.

JOY OF TAX

The 47-year-old represents the Swiss Liberals party. It's the third largest in Switzerland's parliament and stands for a slender state, low taxes and tax competition among cantons. He has distributed copies of the book, which is written in French, to every 20-year-old in Switzerland's sleepy lakeside state of Vaud. He says he wants to reach people who "have never paid taxes but are about to pay them for the rest of their lives."

In the book, he defends the Swiss system, which lets cantons determine two-thirds of the taxation paid by multinationals in Switzerland (the remainder is decided at federal level). He says it works because the system is democratic and not too burdensome, noting that the Swiss tradition of direct democracy means people are regularly consulted.

EBay - headquartered in the central canton of Bern - is one beneficiary of the system. In the past four years, it has paid an average tax rate on overseas income of between 2.5 percent and 3.6 percent - a fraction of the headline tax rate in its major markets - its annual reports show. "Tax rates are important, but it's not the only reason," an eBay spokesman said in an email about the company's choice of base. Location, workforce, infrastructure and quality of life are also important.

In Broulis' canton Vaud, the official rate of corporate tax is nearly 24 percent, but firms often negotiate a better deal. For more than a decade, Broulis has had the final say on whether a foreign company qualifies for special tax regimes, including offers such as up to 10 years tax-free, subject to conditions such as job creation.

"If taxes are too high and confiscatory they become intolerable," Broulis writes. Companies including Yahoo and Brazilian miner Vale have settled in the canton. Vale confirmed tax optimization played a role in its decision, Yahoo declined comment.

Other firms attracted by Switzerland's "ring-fence" include some of the world's biggest commodity firms. Oil traders Vitol and Trafigura, for instance, are based in land-locked Switzerland. Much of their income is generated abroad, so the tax breaks can be ample - usually less than a quarter of earnings they make abroad is taxed. Their headline tax rate can fall to just 11-12 percent of profits, or even less, says a tax official.

Vitol declined to comment and Trafigura stressed its revenue is taxed "either in Switzerland or elsewhere." Nissan said it is "a good corporate citizen in every country in which it operates." Thomson Reuters also benefits from Swiss tax rates. "The specific rates of tax we pay are at the standard Swiss rates as appropriate," a spokesman said by email.

"HOSTAGE TO MULTINATIONALS"

As pressure from the EU has mounted, some firms have started quizzing tax advisers about their options.

"The roots of these companies are fairly transient and if they can get better terms somewhere else, they will consider it," said Gary Klesch, head of Geneva-based commodities trading and production firm Klesch Group.

That has prompted head-scratching among the Swiss as to how to satisfy the EU without scaring firms away. Foreign firms that invest in Switzerland employ 11 percent of the Swiss workforce and contribute to 14 percent of GDP, according to a 2012 Joint Study by the Swiss-American Chamber of Commerce and the Boston Consulting Group. The 23,524 tax-privileged companies resident in Switzerland in 2009 contributed 3.8 billion francs - around half of the total tax income from all companies in the country, according to the finance department.

"The problem is serious. If all these firms were to move away, Switzerland would lose in total up to five billion francs in tax and 10,000 jobs," Eva Herzog, finance director for the canton of Basel said in October.

Some say the cantons have become totally dependent on multinationals. "Cantons are now admitting that if they lose their special tax statuses they will be in complete disarray," said Ada Marra, a lawmaker for the left-wing SP party and member of parliament's economic committee. "Effectively this is an admission that several Swiss cantons are now hostages to big companies."

There are signs that even the Swiss are fed up with firms being offered rock-bottom rates while people feel the squeeze. In Zug - home to commodity trader Glencore and mining company Xstrata - some argue that expats are pricing locals out of the market. Voters in June backed an initiative to increase affordable housing. Glencore declined comment and Xstrata did not respond.

NEGOTIATING TACTICS

Some lawmakers say Switzerland's foot-dragging on the tax issue may have weakened its negotiating position with the EU, which is the destination of more than half its exports and a vital prop for the economy. International pressure has already forced it to agree ways to tax foreigners' cash held in Swiss accounts.

"We have to be smart enough to play the flexibility which we should still have to our advantage," said Armin Marti, a tax and legal partner at PricewaterhouseCoopers in Zurich. "We're not an EU member state, we can still be creative and think of what we can do on the tax base."

Officials say the Swiss Federation is unlikely to meet the EU's year-end deadline, but they are optimistic they can have a tax proposal on the table by next spring. The European Commission has seen progress but says more is needed from the Swiss, said its spokeswoman Treynor: talks will continue and it will report on its findings in June.

Assuming the Swiss system has to change, a presentation co-authored by Switzerland's no. 2 tax official Fabian Baumer, recommended in November that Switzerland should pursue "various and bold" solutions.

One would be to charge even less: cantons could lower the standard corporate rate. It's an approach championed by Geneva, which has suggested slashing the standard rate to 13 percent by 2018 to keep hold of commodity giants. That way the EU could no longer accuse it of "ring fencing," because domestic and foreign income would be taxed at the same rate.

Traders such as Vitol have welcomed the idea. But it would leave a gaping hole in Geneva's budget which would need filling somehow - possibly by other cantons. "In my opinion we can't start subsidizing tax competition," said Christian Wanner, finance minister of the northern canton of Solothurn and president of the cantonal finance ministers.

More innovative ideas could include 'licence boxes' - which allow income resulting from intellectual property to be taxed at lower rates - that are already in place in EU states such as Luxembourg, Cyprus and Belgium and the Swiss canton of Nidwalden.

However, such a solution would not cover commodity firms, now responsible for 3-4 percent of Swiss GDP, according to estimates from the Swiss State Secretariat for Economic Affairs.

There could be incentives that aren't just about tax. Swiss cantons could negotiate discounts on other charges, such as giving companies free electricity, said one finance official, although he said he did not personally agree with the idea.

Switzerland is already fighting back. In October, it lured Greece's biggest company Coca Cola Hellenic, which said Switzerland's stability and ease of doing business were behind its choice.

"Switzerland knows how to preserve its fiscal system which is something that many EU countries haven't been able to do," Broulis told Reuters.

In a one-page letter sent to U.S. companies based in Belgium in early October, the marketing association Greater Zurich Area highlighted negative aspects of the Flemish economy such as rail strikes, massive public debt and the recession.

"Maybe it's time to consider changing your location and moving your regional headquarters from Belgium to Zurich," Swiss press quoted the letter as saying. The authority, which confirmed it sent the note, has since apologized. "We never intended to offend Belgian feelings or denigrate Belgium as an investment location," it said.

(Caroline Copley reported from Zurich; Additional reporting by Tom Miles in Geneva, John O'Donnell in Brussels and Richard Mably and Tom Bergin in London; Edited by Sara Ledwith)

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Source: http://www.newsdaily.com/stories/bre8bh0j0-us-tax-swiss-europe/

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The Most Common Cancer in the World- Basal Cell Carcinoma ...

Most people are aware of skin cancer.? Melanoma, the deadliest type of skin cancer, is by far the most publicized.? However, other type of skin cancers exist, and though not usually deadly, they can still be disfiguring and dangerous, and must be treated.? Basal Cell Carcinoma, referred to by most as BCC, is the MOST common skin cancer.? While Caucasian men over 40 have been known to be more commonly diagnosed with this skin cancer, it is becoming increasingly prevalent among woman, as well as for men and woman under 40. More than 1 million people are diagnosed with BCC annually, and this statistic increases by 10% every year. This increase is attributed to the aging baby boomer population, an increase in UV light exposure (due to depletion of the Earth?s ozone layer), and a lack of appropriate sun protective behaviors.

Once one BCC is diagnosed, the risk of developing a second BCC within 5 years is 50%. While BCC is enough of a concern on its own, the Journal of the National Cancer Institute also found that those diagnosed with any skin cancer are slightly more likely to have another type of cancer, unrelated to the skin. This risk increases even more in those diagnosed with BCC at a younger age. This information makes it clear that preventing BCC, as well as early diagnosis and treatment of BCC is becoming increasingly important.

There are many factors that can increase a person?s risk for BCC, including:

  • chronic sun exposure
  • fair skin type, with red or blonde hair and/or green or blue eyes, or tendency to burn easily and rarely tan (Skin Type l or ll)
  • family or personal history of basal cell or other skin cancers

Less common risk factors are arsenic exposure, therapeutic radiation, chronic immunosuppression ? such as transplant recipients or those with HIV ? and some rare genetic conditions. The strongest cause of BCC is excessive or chronic sun exposure. UV radiation causes a genetic mutation to several tumor suppressing genes, which are part of the ?hedgehog? molecular pathway (important in early fetal development). The malfunction of those genetic ?brakes? allows uncontrolled growth, resulting in basal cell cancer.

The warning signs of BCC include:

  • A persistent sore that remains open and does not heal for several weeks
  • A red patch, that may or may not be irritated, and that does not go away
  • A new, shiny bump. May be red, translucent, white or pigmented
  • A pink, growth with rolled borders and sometimes a central crust. There may also be small blood vessels visible in the growth.
  • A white, yellow, waxy area with undefined borders that may lo0k like a scar

The diagnosis of BCC is made after a small skin biopsy has been performed by your dermatologist, which is sent to a dermatopathologist, who then views the tissue specimen underneath the microscope, and analyzes the histology of the cells. At Krauss Dermatology, we use Miraca Life Sciences? expert dermatopathologists. http://www.miracalifesciences.com/dermatology

A nodular basal cell cancer

Different types of BCC exist and are important to understand when making a clinical decision about the best treatment option. A nodular BCC is the most common type of BCC and is the case in about 60% of confirmed BCC diagnoses. Nodular BCC appears as a pink, pearly bump that usually has a defined border and may have areas of pigmentation or ulceration. Another common BCC is the superficial BCC. These occur in 30% of the cases and are light red and scaly, resembling eczema. An ulcerating BCC is usually firm, translucent, often with a depressed area or crust, and may bleed. A pigmented BCC? may be partially or completely brown or blue, and has a? firm surface that may be depressed. These types of BCC are easy to mistake as a melanoma, and are found more commonly in people with darker complexions, who naturally have more melanin (the molecule that gives skin its color) in their skin.

Treatment options for BCC are varied and depend on the type of BCC, it location and the patient?s overall health, but are all typically done on an outpatient basis. Higher risk locations for BCC include the areas around the eyes, mouth, ears and scalp, where there is risk of cosmetic and functional impairment, and increased risk of recurrence. Foregoing or delaying treatment usually results in extensive damage to the local surrounding tissues, but in extremely rare instances, the cancer can metastasize to other organs and tissues.

Electrodessication and curettage is an option if the BCC is nodular or superficial, smaller than 1cm, in a low risk area(such as the trunk, arms and legs), and is now an aggressive subtype. This procedure requires local

2 Superficial Basal Cell Cancers on the chest, marked with green surgical marker prior to electrodessication and curettage treatment.

anesthetic and then the malignant tissue is scraped away and electrically cauterized a total of three times. This process destroys the malignant tissue, leaving surrounding normal skin intact, with a saucer shaped wound that can take up to 4-6 weeks to heal.

Another option to removed BCCs is with surgical excision. A local anesthetic is used, and the malignant tissue is surgically excised. A local anesthetic is used, and the malignant tissue is surgically excised with a margin of normal skin tissue around the edges minimize risk that there will be any remaining malignant cells from that lesion. This specimen is then sent for pathology to validate these margins are negative. This procedure is best for BCCs that are in a high risk area, for small and large lesions, and if definitive pathology is wanted for more aggressive type BCCs.

Mohs surgery, named after the physician who created it, is a surgical procedure performed by a specially trained dermatologic surgeon. This treatment option is best for BCCs with an aggressive growth pattern (determined by pathology) and for those in high risk areas and where removing the least amount of tissue is important, such as the face. A Mohs surgeon will remove the visible malignant tissue and look at it underneath the microscope while the patient waits. If there are still malignant cells at the border of the specimen ? indication it is not completely removed -? the surgeon will go back and remove more and again look at it underneath the microscope. This will be done until there are no remaining, microscopically visible malignant cells. Mohs surgery has the high cure rate of any procedure for both BCC and for the more worrisome Squamous Cell Carcinoma of the skin, but is covered by insurance for specific types and locations of BCC only.

Other, less invasive, treatment options includes treatment with a topical agent, called Imiquimod (Aldara). this is the best for low risk, superficial BCC and is used once daily for 6-12 weeks. Less commonly used treatments with a lower cure rate than surgery are photodynamic light therapy (PDT) and cryotherapy (freezing). In the rare instances of metastasis or advanced local spread of the basal cell cancer, a new medication, Vismodegib can be used. Vismodegib was approved by the FDA in January 2012 and is 90% effective at inhibiting a molecular process in the ?hedgehog pathway? that prevents tumor genes from being activated. This medication is currently in clinical trials to treat other types of cancers such as colon, lung, and pancreatic tumors, and has shown some success in managing patients with rare genetic disorders causing multiple BCCs.

Prevention of sun damage is crucial to thwarting a diagnosis of BCC. This means using moisturizers with SPF 30 or higher on a daily basis, applying sunscreens correctly when in direct sunlight (reapplication every 2 hours is important), using appropriate types of sunscreens (UVA/UVB or broad spectrum), avoiding excessive sun exposure whenever possible between 11am and 3pm, seeking shade, wearing long sleeve shirts and wide-brimmed hats, avoiding tanning and burning, and taking vitamin D supplements. Of course, avoiding the use of UV tanning booths is imperative to decrease your risk of BCC, Squamous Cell Carcinoma and Melanoma.

Early detection of BCC will help you avoid more extensive and invasive treatments. Monthly self-skin exams, visting your dermatologist for your regular skin exam, and notifying your doctor of any new or changing lesions are important. The free iPhone/iPad application ?UMSkin check? can help you identify new or changing skin lesions quickly. Visit?http://www.aad.org/spot-skin-cancer for skin cancer information and tips on performing your monthly self-skin exam.

Kalei Ensminger, RN, Krauss Dermatology

Family Nurse Practitioner Student, Regis College

Madeline Krauss, MD

Dermatologist Krauss Dermatology

This entry was posted on Wednesday, December 19th, 2012 at 7:51 pm and is filed under Uncategorized. You can follow any responses to this entry through the RSS 2.0 feed. Responses are currently closed, but you can trackback from your own site.

Comments are closed.

Source: http://www.kraussderm.com/uncategorized/the-most-common-cancer-in-the-world-basal-cell-carcinoma-3

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Wednesday, December 19, 2012

THE COST OF SPENDING: National Debt Nears 'Dangerous' Level

The national debt clock is spinning faster every year.?

At last check, it was approaching $16.4 trillion. Just four years ago, it was $10.6 trillion.?

The skyrocketing number is, to say the least, reason for concern for every American.?

Here's why:?

As of today, every household in the United States owes about $140,000 of this debt.?

The country is borrowing roughly $6 billion every day, and $239 million every hour. Put another way, that's $4 million every minute.?

The country runs up so much debt for a fairly basic reason -- it spends far more than it takes in. This year, for every dollar in revenue the federal government brought in, it spent two dollars and six cents. That shortfall over the course of the year adds up to the annual deficit. The national debt -- or total accumulated debt -- is the sum of all annual deficits, minus any surpluses.?

Politicians talk about deficits and the debt all the time. But how to get politicians to come to some agreement to get the debt clock to slow down, or even tick back the other way, continues to be a challenge.

It might help to look at the arc of the national debt over the decades.?

Throughout U.S. history, while the amount America owes has ebbed and flowed, our habit of spending more than we take in is nothing new.?

While the U.S. is currently at the highest level of debt ever, 1835 saw the lowest-recorded debt at just $34,000 under President Andrew Jackson. There was an unsuccessful assassination attempt on him that year.?

In 1865, a president who was killed in an assassination attempt, Abraham Lincoln, oversaw a debt of $3 billion.?

The numbers would eventually grow.?

Fast forward to "Black Tuesday" in 1929, the most devastating stock market crash in U.S. history, and the national debt rose to $17 billion.?

Then came World War II, and by D-Day in 1945, the debt had ballooned to $259 billion.?

Following the 2008 financial crisis -- which is often referred to as the start of the worst financial crisis since the Great Depression -- the debt crossed the $10 trillion mark.?

And it continues to rise, well past $16 trillion today.?

Economist Robert Genetski, author of the book "Classical Economic Principles & the Wealth of Nations," believes history shows that when government spending increases much faster than spending in the overall economy, the private sector and economy overall suffers.?

"(From) 1945-1947, there was a huge cut in government spending because of the winding down from WWII, and the people who thought government spending was holding the economy up were all predicting a major depression at that time," he said.?

"What happened was for the first time in 15-16 years there was a huge increase in private spending on goods and services per person ... and that was the real recovery. The recovery wasn't World War II when we were fighting for our survival and spending money to ensure that survival, the real recovery came after World War II."?

Bill Clinton's budget director Alice Rivlin noted the challenge in curbing spending.?

"Many people rail about the government does too much -- on the other hand, as soon we have a serious storm they are saying the government hasn't done enough. So you have to be very specific about this," she said. "The driving force for additional government spending is not discretionary spending. It's this coming tsunami of older people that we have to cope with and, yes, we expect Medicare spending to grow. And the question is does it have to grow that fast, and I don't think it does."?

John Taylor, a Stanford University economist, said because of the interest on the debt, time is running out to deal with the problem.?

"There's lots of people that will lend to us so far as long as our debt doesn't get so large they become suspicious that we'll pay it back," he said. "If we don't correct this problem, interest will tend to dominate our whole spending -- it'll be greater than defense or Social Security.?

"We have history to guide us. When debt gets too high, people are skeptical about lending, then you run into a crisis like we've seen in Greece and many other countries. ?So it's dangerous when it gets too high, and we are moving close to that dangerous level every day."

Source: http://www.foxnews.com/politics/2012/12/18/cost-spending-national-debt-nears-dangerous-level/

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Tuesday, December 18, 2012

Ants aquaplaning on a pitcher plant

Dec. 18, 2012 ? An insect-trapping pitcher plant in Venezuela uses its downward pointing hairs to create a 'water slide' on which insects slip to their death, new research reveals. The research was published December 19, in the journal Proceedings of the Royal Society B.

Hairs on plants, called trichomes, are typically used to repel water. However, the Cambridge researchers observed that the hairs on the inside of Heliamphora nutans pitcher plants were highly wettable, prompting them to test whether this phenomenon is related to the trapping of insects.

They found that wetting strongly enhanced the slipperiness of the trap and increased the capture rate for ants almost three-fold -- from 29 per cent when dry to 88 per cent when wet. Upon further examination, they found that the wetting affected the insects' adhesive pads while the directional arrangement of the hairs was effective against the claws.

Dr Ulrike Bauer, lead author of the paper from the University of Cambridge, said: "When the hairs of the plant are wet, the ants' adhesive pads essentially aquaplane on the surface, making the insects lose grip and slip into the bowl of the pitcher. This is the first time that we have observed hairs being used by plants in this way, as they are typically used to make leaves water repellent."

They also found that the plant used a wicking method during dryer times to pull moisture from the bowl of the pitcher up to the hairy trapping surface, enabling them to capitalise on this aquaplaning effect even when there is no rain.

Dr Bauer added: "This very neat adaptation might help the plants to maximise their nutrient acquisition."

The Heliamphora nutans pitcher plant lives on the spectacular table mountains of the Guyana Highlands in Southern Venezuela, between altitudes of 2000-2700m. The pitchers can grow up to 18 cm tall and 7 cm wide and trap mainly ants.

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The above story is reprinted from materials provided by University of Cambridge, via EurekAlert!, a service of AAAS.

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Journal Reference:

  1. Ulrike Bauer et al. 'Insect aquaplaning' on a superhydrophilic hairy surface: how Heliamphora nutans Benth. pitcher plants capture prey. Proceedings of the Royal Society B, December 19, 2012

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/m0U_-2WvPJo/121218203513.htm

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